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yr2000 nov research 001127 html

Bioinformatics, Genomics, and Proteomics
Christopher Smith | Nov 26, 2000 | 10+ min read
Data Mining Software for Genomics, Proteomics and Expression Data (Part 1) Data Mining Software for Genomics, Proteomics and Expression Data (Part 2) High-throughput (HT) sequencing, microarray screening and protein expression profiling technologies drive discovery efforts in today's genomics and proteomics laboratories. These tools allow researchers to generate massive amounts of data, at a rate orders of magnitude greater than scientists ever anticipated. Initiatives to sequence entire genom
Up to Speed on PCR
Deborah Fitzgerald | Nov 26, 2000 | 7 min read
Real-time PCR Systems Cepheid's Smart Cycler System PCR--a technique so common in today's laboratories that it is easy to forget its revolutionary impact--enables the specific amplification and detection of as little as a single copy of a particular nucleotide sequence. However, PCR has the potential to be used not just for the detection of specific sequences, but also for their quantification, because of the quantitative relationship between the amount of starting target sequence and the amoun
Production Genomics
Dave Amber | Dec 10, 2000 | 8 min read
Courtesy of William Ghiorse (2 Termononaspora images) and Margie Romine (Sphingomonas image)The two images at left are of Termononaspora fusca.Right: Sphingomonas aromaticivorans Be forewarned. Visitors to Walnut Creek, Calif., may want to leave their pets at home to keep them from becoming fodder for gene sequencers. The Joint Genome Institute (JGI) at Walnut Creek, genome central for the U.S. Department of Energy, is one of the largest sequencing operations in the world, where "it turns out it
Female Leaders Of Science Report Cracks In Glass Ceiling
Robert Finn | Nov 23, 1997 | 9 min read
More women are attaining policymaking positions, but the pipeline issue and significant barriers to advancement remain Women are becoming increasingly visible at leadership levels in science. M.R.C. Greenwood, the former associate director in the Office of Science and Technology Policy, likes to point out that in recent years women have headed the two most important Cabinet departments related to science-the departments of Energy and Health and Human Services. Additionally, she notes, women h
A Double Life for a Very Visible Human
Tom Hollon | Nov 12, 2000 | 6 min read
Joseph Paul Jernigan, 38, executed Texas murderer, flourishes in his resurrection in cyberspace and shows every sign of fulfilling his promise as a peerless instructor of anatomy and unique teacher of surgeons. He is also a champion sportsman whose versatility no single mortal can match. Jernigan, a.k.a. the National Library of Medicine's Visible Male, came under the spotlight of research medicine in 1994, in the form of a 15-gigabyte dataset of digitized photographs of 1,878 coronal slic
Preimplantation Genetic Diagnosis: The Next Big Thing?
Ricki Lewis | Nov 12, 2000 | 9 min read
Courtesy of David Hill, ART Reproductive Center Inc.Two separated blastomeres subjected to FISH analysis to check the chromosomes. In early October, preimplantation genetic diagnosis (PGD) made headlines when a Colorado couple used assisted reproductive technology (ART) to have a baby named Adam, whose umbilical cord stem cells could cure his six-year-old sister Molly's Fanconi anemia.1 When Adam Nash was a ball of blastomere cells, researchers at the Reproductive Genetics Institute at Illinois
At Mid-Decade, Forecasters Taking A Look Into Science And Technology Crystal Ball
Karen Young Kreeger | Dec 10, 1995 | 10 min read
Sidebar: A Checklist for Evaluating Forecasts With the year 2000 approaching, scientific, environmental, technology, and health organizations have been making predictions about the state of science and technology in the next five years and beyond, as have some individuals. Many such agencies and associations are also using the approaching turn of the century to set goals for themselves. Should the predictions come true and the goals be met by the start of the next century, forecasters anticipa
Assays by the Score
Deborah Fitzgerald | May 27, 2001 | 9 min read
Click to view the PDF file: Bead-based Fluorescent Multiplex Protein Analysis Systems Courtesy of LINCO ResearchLabMAP-based systems use internally dyed fluorescent microspheres to analyze as many as 100 different analytes concurrently. Today's competitive, high-paced research environment has stimulated the development of a host of approaches for rapid, cost-efficient analyses of large numbers of samples. In keeping with this trend, methods for simultaneously analyzing multiple species in a g
University Bargains with Students' Rights
Karen Young Kreeger | Nov 11, 2001 | 5 min read
Three years ago, the University of California, Berkeley, plant and microbial biology (PMB) department negotiated an exclusive research relationship with Novartis Agricultural Research Institute that allowed the company to review graduate student and postdoc work before publication. But the university didn't consult the students before trading away their intellectual property rights, provoking lasting anger and confusion, according to a sociologist's report commissioned by the university. Many
Keeping Time with Drosophila
Laura Bonetta | Feb 3, 2002 | 10 min read
Circadian clocks—the biological timekeepers that operate on a daily cycle—keep virtually every living creature in tune with its environment. These internal clocks regulate a wide range of fundamental biological processes, including movement, smell, sleep, mating, and feeding. A true circadian clock is endogenous; that is, it keeps time even in the absence of external cues. The clock can, however, be reset, or entrained, by daylight, allowing the synchronization of circadian rhythms t

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