A few weeks ago
I chided Nick Wade (lovingly! I?m a huge fan, after all) for invoking the ?code? word when describing a study on nucleosome positioning. It surprised me when my post spurred some comments on the nature of the
Nature press office, and their proclivity for hyping, but ?not overhyping,? the research papers within. Wade can be forgiven. I didn?t realize how pervasive the word code had been in
Nature until I saw the disturbingly assonant headline on the cover of the issue. -- ?The Chromatin Code Decoded.? And in all fairness,
Nature and their press office deserve some slack. They?re trying to generate interest in and sell their magazine, and I?ll be happy when science magazines like
Nature (62,000) sport more subscribers than
Cosmopolitan (940,000).
Some of the skeptics of the
histone code hypothesis have told me they get the sense that people love to use the word ?code? to describe their work because it?s marketable. While it?s not a completely unfounded observation, I understand the urge to see some sort of neat and readable codified message in life?s instructions. Few codes in nature will be quite as cut and dry as the genetic code. But when faced with the dizzying complexity of biological processes, it's natural for scientists to hope that some might follow a similarly simple set of rules.
Alas, this might not be one of those cases. In a
news and views that accompanied the nucleosome-positioning code article, Timothy Richmond at the ETH Z?rich, Institut f?r Molekularbiologie und Biophysik, Switzerland, raises some interesting caveats about the ability of this new algorithm to predict nucleosome positioning strictly from DNA sequence. An interesting black box is the role of the linker histone H1, which acts to space nucleosomes in many eukaryotic genomes, but not in yeast (which the study largely worked with). Richmond points to some fascinating mouse work in which researchers deleted several copies of H1 and found that nucleosomes naturally packed much tighter. So, nucleosome spacing can?t be
completely directed by something encoded by the DNA sequence. It?s an interesting hypothesis, and one that?s captured my imagination, but it?s going to require some more testing in various eukaryotic genomes.