50 Years Ago in Pharmacology

The first chemical method of measuring levels of catecholamine

Editor's note: Citation Classics Commentaries were written by the authors of some of the studies that were the most highly cited papers between 1961 and 1975. The essays were originally published between 1977 and 1993 in Current Contents, a publication of the Institute for Scientific Information (ISI), now Thomson Scientific. (ISI was founded by Eugene Garfield, also the founder of The Scientist.) In this edited essay, published in 1979, neuropharmacologist Arvid Carlsson recalls a 1958 paper describing a method for quantifying adrenaline and noradrenalin in tissue extracts.

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