The Scientist : Neurons need cholesterol to establish contacts [12/11/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Neurons need cholesterol to establish contacts

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20011112-02

Published

12 November 2001

The formation of synapses during brain development, which plays a crucial role in learning and memory, is mediated by molecular mechanisms that remain elusive. In November 9 Science Daniela Mauch and colleagues from Max-Delbrück-Center for Molecular Medicine, Berlin, Germany and the Centre de Neurochimie, Strasbourg, France show that a factor derived from glial cells which strongly promotes synapse development is actually a cholesterol molecule complexed to apolipoprotein E (apoE).

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