The Scientist : Unlocking the secrets of anthrax toxicity [2/11/2001]

Unlocking the secrets of anthrax toxicity

Email: Vicki Glaser - vpglaser@aol.com
News from The Scientist 2001, 2(1):20011102-03

2 November 2001

In an elegant piece of deadly biology, the anthrax-causing bacterium, Bacillus anthracis, produces three proteins that can kill its host. One of these proteins, called protective antigen (PA), is a little like a Trojan horse in that it smuggles the other two proteins — lethal factor (LF) and oedemal factor (OF) — into the host cell. Once in the cell, LF and OF set in motion a train of potentially fatal events.

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