The Scientist : Protecting colonic mucosa [5/9/2001]

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20010905-02

5 September 2001

Short-chain fatty acids (SCFAs) — produced in the colon by bacterial fermentation of dietary carbohydrates — have considerable cytoprotective properties, although the mechanisms behind this phenomenon remain unclear. In September Gastroenterology, Hongyu Ren and colleagues from The University of Chicago, Illinois, show that SCFAs induce intestinal epithelial heat shock protein 25 (hsp25) expression which protects colonic cells against oxidant injury.

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