The Scientist : Circulating DNA fragments involved in vasculitis [11/7/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Circulating DNA fragments involved in vasculitis

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010711-02

Published

11 July 2001

Vasculitis is a key pathogenic element in systemic lupus erythematosus (SLE) and results from activation of immune system triggered by unknown molecular mechanisms. In July Annals of Rheumatic Diseases, Miyata and colleagues at the Fukushima Medical University School of Medicine, Fukushima City, Japan, show that oligodeoxynucleotides (ODN) containing the CpG motif in the sera of patients with SLE may be implicated in vasculitis through activation of proinflammatory cytokines and expression of ICAM-1.

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