The Scientist : Minor histocompatibility antigen has anti-leukaemic role [2/7/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Minor histocompatibility antigen has anti-leukaemic role

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010702-02

Published

2 July 2001

Stem cell transplantation in patients with leukaemia brings along donor immune cells that are the cause of graft-versus-host disease. But, the same cells can have a beneficial effect by eradicating residual malignant haematopoietic cells through the so-called graft-versus-leukaemia effect. In July Nature Medicine, Pierre Fontaine and colleagues from Guy-Bernier Research Center, Maisonneuve-Rosemont Hospital, Montreal, show how a single immunodominant minor histocompatibility antigen can enhance the curative graft-versus-leukaemia effect while removing the graft-versus-host rejection.

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