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Protein Kinase C isozymes in colon carcinogenesis
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010606-02
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Decreased expression of protein kinase C (PKC)-δ can induce colonic tumours, but the effect of increased expression and the underlying molecular mechanisms remain unknown. In June Gastroenterology Sonia Cerda and colleagues from the University of Chicago show that increased expression of PKC-δ inhibits anchorage-dependent and -independent growth, while inducing cellular differentiation and limiting survival in human colon cancer cell lines.
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