The Scientist : Caretakers and gatekeepers [14/3/2001]

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by Jonathan Weitzman

RESEARCH ROUND-UP

Caretakers and gatekeepers

A study of knockout mice reveals complex interactions between the ATM protein and non-homologous end-joining factors.

Email: Jonathan Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20010314-01

Published

14 March 2001

Cellular gatekeepers include the proteins that regulate cell cycle progression in response to DNA damage, and the DNA repair pathways function as genomic caretakers. The p53 and ATM (ataxia-telangiectasia-mutated) proteins behave as cellular gatekeepers, whereas the non-homologous end-joining (NHEJ) DNA repair machinery acts as a genomic caretaker. NHEJ factors include Ku70, Ku80 and the DNA-PK enzyme, plus XXRC4 and DNA Ligase IV (Lig4), which function in ligation.

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