The Scientist : genotype influences chemotherapy results [9/3/2001]

GSTT1 genotype influences chemotherapy results

Children with GSTT1-negative genotype have a greater toxicity and reduced survival after chemotherapy for acute myeloid leukaemia compared with children with at least one GSTT1 allele.

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010309-02

Published

9 March 2001

Oxidative stress has been implicated in the metabolism of chemotherapy drugs. The mechanisms have been linked to the genes that encode glutathione S-transferase (GST) which are critical in protection against oxidative stress.

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