The Scientist : BAG-1 can predict survival from breast cancer [6/3/2001]

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by Tudor Toma

RESEARCH ROUND-UP

BAG-1 can predict survival from breast cancer

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010306-01

Published

6 March 2001

Measuring tumour levels of the protein BAG-1 can predict which women with localised breast cancer are at greatest risk of metastases, according to a paper in the February Journal of Clinical Oncology . Bruce Turner, from Thomas Jefferson University in Philadelphia, and colleagues studied 122 women with early stage breast cancer. They analysed paraffin blocks of excised tumors and found that cytosolic immunostaining for BAG-1 — a protein that inhibits apoptosis — was greater in 79 of 122 invasive breast cancers.

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