The Scientist : Finding an Alzheimer-FAT link [19/7/2004]

The Scientist 2004, 18(14):35

19 July 2004

Constantly on the run, membrane-bounded organelles (MBOs) in neurons deliver proteins from cell bodies to axons. A recent study by Scott Brady and colleagues at the University of Illinois suggests that disruption of this anterograde fast axonal transport (FAT) may contribute to Alzheimer disease pathogenesis via a novel pathway locally regulating glycogen synthase kinase-3 (GSK3) activity.[1]

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