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Untangling Protein Knots in the Brain
The Scientist 2004, 18(13):37
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Whether aggregation of normal protein into tangles is the cause or effect of neurodegenerative diseases such as Alzheimer and Creutzfeldt-Jakob remains unclear. Nevertheless, a number of biotechnology companies are looking at ways to prevent seeding of these proteins. St. Louis-based Novactyl recently was awarded US patent 6,743,771 for a method of blocking protein aggregation using picolinic acid.
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