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Making Mammalian Chromosomes
The Scientist 2004, 18(10):35
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One traditional gene-therapy method relies on homologous recombination. The desired gene segment is placed on a small plasmid and delivered by virus or liposome, but this approach has variable expression levels and instability, and is limited by a small insert size. Yeast artificial chromosomes circumvent some of these problems, but YACs cannot be propagated in mammalian cells. Now a team of scientists at DNAVEC Research of Ibaraki, Japan, has come up with a solution: They have developed a method to create artificial mammalian chromosomes.
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