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A Deadly Selection
Mathematics models the evolution of intractable cancers
The Scientist 2004, 18(5):28
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Natural selection remains modern biology's leitmotif 145 years after Darwin published On the Origin of Species: Tumor resistance offers a devastating reminder of its potency. Clinicians often hope they have destroyed a tumor, only to see the malignancy reemerge with renewed vigor. Now, new and increasingly sophisticated mathematical analyses model the driving forces behind resistance in unprecedented detail. Such systems modeling cancer evolution could eventually allow clinicians to help direct selection and break down cancer resistance.
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