The Scientist : Journal Entries From the Heart [1/3/2004]

The Scientist 2004, 18(4):31

1 March 2004

Like ants marching to an unspoken command, embryonic heart cells follow distinct orders for organ formation, according to a group at the Pasteur Institute. Although many cardiac regulator genes have been isolated, researchers do not understand the cellular mechanisms that form a four-chambered heart from a simple tube. To track dividing cells in an embryonic mouse heart, researchers in Margaret Buckingham's lab created a transgenic line harboring an inactivated reporter gene called nlaacZ.

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